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KMID : 0603820170230040295
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Journal of Experimental & Biomedical Science
2017 Volume.23 No. 4 p.295 ~ p.302
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RANK Signaling Pathways and Key Molecules Inducing Osteoclast Differentiation
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Lee Na-Kyung
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Abstract
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Mononuclear osteoclast precursors derived from hematopoietic progenitors fuse together and then become multinucleated mature osteoclasts by macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL). Especially, the binding of RANKL to its receptor RANK provides key signals for osteoclast differentiation and bone-resorbing function. RANK transduces intracellular signals by recruiting adaptor molecules such as TNFRassociated factors (TRAFs), which then activate mitogen activated protein kinases (MAPKs), Src/PI3K/Akt pathway, nuclear factor-κB (NF-κB) and finally amplify NFATc1 activation for the transcription and activation of osteoclast marker genes. This review will briefly describe RANKL-RANK signaling pathways and key molecules critical for osteoclast differentiation.
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KEYWORD
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Osteoclast differentiation , RANK signaling, RANKL
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